Evaluating the Impacts of Virtual Organization Absorption on the Quality of Urban Private Constructions; the System Dynamics Approach

Quality compliance checking of urban private constructions in Iran follows a fragmented pattern. By considering this fragmentation along with the inherent complexities of the quality compliance checking, it becomes urgent to look closer at this mechanism to find a way for making improvements. Since there is no determination to change the existing mechanism, this study discusses the use of virtual organizations as a strategy to enhance the level of quality. To this end, according to the intended approach for developing virtual organizations, this study identifies the capabilities of this type of systems in the first step. Then, this research evaluates the impacts of virtual organization absorption on the quality of urban private constructions. In this evaluation, the paper applies the system dynamics approach as the modeling tool due to its ability to address complexities and feedback structures. The resulted dynamic model needs initial values and requires functions to be able to run the simulation. In this case, the Delphi Technique is used to extract the functions and the values. After importing the resulted values and functions into the model, the focus group is used for the validation. The result of this analysis represents the positive impacts of the virtual organization absorption in the quality compliance checking mechanism. Fifty-percent improvement in the quality level of urban private constructions after a twenty-year period is one of the results, which could be considered as an indicator of virtual organization impacts.

     

The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups

Chromosome 17 abnormalities are often observed in medulloblastomas (MBs), particularly those classified in the consensus Groups 3 and 4. Herein we review MB signature genes associated with chromosome 17 and the relationship of these signature genes to the ubiquitin-proteasome system. While clinical investigators have not focused on the ubiquitin-proteasome system in relation to MB, a substantial amount of data on the topic has been hidden in the form of supplemental datasets of gene expression. A supplemental dataset associated with the Thompson classification of MBs shows that a subgroup of MB with 17p deletions is characterized by reduced expression of genes for several core particle subunits of the beta ring of the proteasome (β1, β4, β5, β7). One of these genes (PSMB6, the gene for the β1 subunit) is located on chromosome 17, near the telomeric end of 17p. By comparison, in the WNT group of MBs only one core proteasome subunit, β6, associated with loss of a gene (PSMB1) on chromosome 6, was down-regulated in this dataset. The MB subgroups with the worst prognosis have a significant association with chromosome 17 abnormalities and irregularities of APC/C cyclosome genes. We conclude that the expression of proteasome subunit genes and genes for ubiquitin ligases can contribute to prognostic classification of MBs. The therapeutic value of targeting proteasome subunits and ubiquitin ligases in the various subgroups of MB remains to be determined separately for each classification of MB.     

伊朗伊斯法罕地区的步甲科（鞘翅目）记述

步行虫（鞘翅目：步甲科）作为强劲的捕食者,对农业害虫和森林害虫的生态学控制起着举足轻重的作用.本文研究了伊朗中部伊斯法罕地区的有益步行虫,共收集确定了42个种与亚种,来自7个亚科Broscinae、Carabinae、Cicindelinae、Harpalinae、Nebriinae和Pterostichinae.这其中有6种是伊朗区系的新记录种,分别是〖WTBX〗Cephalota 〖WTBZ〗(〖WTBX〗Taenidia〖WTBZ〗) 〖WTBX〗circumdata cappadocica 〖WTBZ〗Franzen,〖WTBX〗Lophyridia concolor concolor 〖WTBZ〗Dejean,〖WTBX〗Lophyridia littoralis mandli 〖WTBZ〗Mandl,〖WTBX〗Ophonus 〖WTBZ〗(s.str.) 〖WTBX〗cribricollis 〖WTBZ〗(Dejean),〖WTBX〗Pachycarus 〖WTBZ〗(〖WTBX〗Paramystropterus〖WTBZ〗)〖WTBX〗 bravipennis 〖WTBZ〗Chaudoir和 〖WTBX〗Cymindis 〖WTBZ〗(s.str.) 〖WTBX〗scapularis 〖WTBZ〗Schaum.     

Effects of protonation and deprotonation on the reactivity of quinolone: A theoretical study

Quinolones are the subject of much research as antibacterial compounds and as a new class of antitumor agents.The protonation(P) and deprotonation(D) sites and conformations of quinolone were investigated.The proton affinity(PA) on each of the possible sites in 4-oxo-1,4-dihydroquinoline has been calculated by the restricted Hartree-Fock(HF) and density functional theory(DFT) methods with the basis set 6-311G**.The O-site of protonation was found to be strongly favored over the N-site for the studied compound in the gas phase.Deprotonation takes place in quinolone by detachment of the N-H and COOH protons.The PA of the simple quinolone molecule was used to characterize quinolone reactivity with DNA binding sites.The relative stabilities of the syn and anti conformations were investigated at the B3LYP/6-311G** level of theory;the syn form was shown to be slightly more stable.Its conformation seems to be intrastabilized by hydrogen-bonds consisting of a hydroxyl proton with the O10 atom as the acceptor.We computed and discussed the charge-density distribution and electrostatic potential to explain the reactivity of quinolone.